CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Aclacinomycin methylesterase RdmC

Enzyme Information

3.1.1.95
Aclacinomycin methylesterase.
based on mapping to UniProt Q54528
Aclacinomycin T + H(2)O = 15-demethylaclacinomycin T + methanol.
-!- The enzyme is involved in the modification of the aklavinone skeleton in the biosynthesis of anthracyclines in Streptomyces species.

UniProtKB Entries (1)

Q54528
RDMC_STREF
Streptomyces purpurascens
Aclacinomycin methylesterase RdmC

PDB Structure

PDB 1Q0Z
External Links
Method X-RAY DIFFRACTION
Organism Streptomyces
Primary Citation
Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism.
Jansson, A., Niemi, J., Mantsala, P., Schneider, G.
J.Biol.Chem.