CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Tyrosine-protein kinase

Enzyme Information
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P12931
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Proto-oncogene tyrosine-protein kinase Src

PDB Structure

PDB 1O45
External Links
Organism Escherichia
Primary Citation
Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
Lange, G., Lesuisse, D., Deprez, P., Schoot, B., Loenze, P., Benard, D., Marquette, J.P., Broto, P., Sarubbi, E., Mandine, E.