CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside phosphorylase domain
Functional Family MTA/SAH nucleosidase family protein

Enzyme Information

3.2.2.9
Adenosylhomocysteine nucleosidase.
based on mapping to UniProt P0AF12
S-adenosyl-L-homocysteine + H(2)O = S-(5-deoxy-D-ribos-5-yl)-L- homocysteine + adenine.

UniProtKB Entries (1)

P0AF12
MTNN_ECOLI
Escherichia coli K-12
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

PDB Structure

PDB 1NC3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysis.
Lee, J.E., Cornell, K.A., Riscoe, M.K., Howell, P.L.
J.Biol.Chem.