CATH Domain 1mhwD00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.50	OB fold (Dihydrolipoamide Acetyltransferase, E2P)
	2.40.50.170	Cysteine proteinases. Chain C

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases. Chain C
Functional Family	Cathepsin L1

Enzyme Information

3.4.22.15

Cathepsin L.

based on mapping to UniProt P07711

Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.

-!- A lysosomal enzyme that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN(2) or the epoxide inhibitor E-64. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P07711

CATL1_HUMAN

Homo sapiens

Cathepsin L1

PDB Structure

PDB	1MHW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Pichia
Primary Citation	Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides Chowdhury, S., Sivaraman, J., Wang, J., Devanathan, G., Lachance, P., Qi, H., Menard, R., Lefebvre, J., Konishi, Y., Cygler, M., Sulea, T., Purisima, E.O. J.Med.Chem.