CATH Classification

Domain Context

CATH Clusters

Superfamily Rieske [2Fe-2S] iron-sulphur domain
Functional Family Cytochrome b-c1 complex subunit Rieske, mitochondrial

Enzyme Information

7.1.1.8
Quinol--cytochrome-c reductase.
based on mapping to UniProt P13272
Quinol + 2 ferricytochrome c(Side 2) = quinone + 2 ferrocytochrome c(Side 2) + 2 H(+)(Side 2).
-!- The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain. -!- It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria. -!- The mammalian enzyme contains cytochromes b-562, b-566 and c(1), and a 2-iron ferredoxin. -!- Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non- cytoplasmic compartment (cf. EC 1.6.99.3). -!- Formerly EC 1.10.2.2.

UniProtKB Entries (1)

P07552
QCR10_BOVIN
Bos taurus
Cytochrome b-c1 complex subunit 10

PDB Structure

PDB 1L0N
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Famoxadone: The Role of Aromatic-Aromatic Interaction in Inhibition
Gao, X., Wen, X., Yu, C.A., Esser, L., Tsao, S., Quinn, B., Zhang, L., Yu, L., Xia, D.
Biochemistry