CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha-D-phosphohexomutase, C-terminal domain
Functional Family Phosphoglucomutase

Enzyme Information

5.4.2.2
Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).
based on mapping to UniProt P47244
Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
-!- Maximum activity is only obtained in the presence of alpha-D-glucose 1,6-bisphosphate. -!- This bisphosphate is an intermediate in the reaction, being formed by transfer of a phosphate residue from the enzyme to the substrate, but the dissociation of bisphosphate from the enzyme complex is much slower than the overall isomerization. -!- Also, more slowly, catalyzes the interconversion of 1-phosphate and 6-phosphate isomers of many other alpha-D-hexoses, and the interconversion of alpha-D-ribose 1-phosphate and 5-phosphate. -!- Cf. EC 5.4.2.5. -!- Formerly EC 2.7.5.1.

UniProtKB Entries (1)

P47244
PGM1_PARTE
Paramecium tetraurelia
Phosphoglucomutase-1

PDB Structure

PDB 1KFQ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure analysis of the exocytosis-sensitive phosphoprotein, pp63/parafusin (phosphoglucomutase), from Paramecium reveals significant conformational variability.
Muller, S., Diederichs, K., Breed, J., Kissmehl, R., Hauser, K., Plattner, H., Welte, W.
J.Mol.Biol.