CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Polyamine aminopropyltransferase

Enzyme Information

2.5.1.16
Spermidine synthase.
based on mapping to UniProt Q9WZC2
S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl- 5'-thioadenosine + spermidine.
-!- The enzymes from the plant Glycine max and from mammalia are highly specific for putrescine as the amine acceptor. -!- The enzymes from the bacteria Escherichia coli and Thermotoga maritima prefer putrescine but are more tolerant toward other amine acceptors, such as spermidine and cadaverine. -!- Cf. EC 2.5.1.22 and EC 2.5.1.23.

UniProtKB Entries (1)

Q9WZC2
SPEE_THEMA
Thermotoga maritima MSB8
Polyamine aminopropyltransferase

PDB Structure

PDB 1JQ3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor.
Korolev, S., Ikeguchi, Y., Skarina, T., Beasley, S., Arrowsmith, C., Edwards, A., Joachimiak, A., Pegg, A.E., Savchenko, A.
Nat.Struct.Biol.