CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.870 | DHBP synthase |
|
3.90.870.10 | DHBP synthase |
Domain Context
CATH Clusters
| Superfamily | DHBP synthase |
| Functional Family | 3,4-dihydroxy-2-butanone 4-phosphate synthase |
Enzyme Information
| 4.1.99.12 |
3,4-dihydroxy-2-butanone-4-phosphate synthase.
based on mapping to UniProt P0A7J0
D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.
-!- The reaction involves an intramolecular skeletal rearrangement, with the bonds in D-ribulose 5-phosphate that connect C-3 and C-5 to C-4 being broken, C-4 being removed as formate and reconnection of C-3 and C-5. -!- The phosphorylated four-carbon product (L-3,4-dihydroxybutan-2-one 4-phosphate) is an intermediate in the biosynthesis of riboflavin.
|
UniProtKB Entries (1)
| P0A7J0 |
RIBB_ECOLI
Escherichia coli K-12
3,4-dihydroxy-2-butanone 4-phosphate synthase
|
PDB Structure
| PDB | 1IEZ |
| External Links | |
| Method | SOLUTION NMR |
| Organism | Escherichia |
| Primary Citation |
The NMR structure of the 47-kDa dimeric enzyme 3,4-dihydroxy-2-butanone-4-phosphate synthase and ligand binding studies reveal the location of the active site.
Proc.Natl.Acad.Sci.USA
|