CATH Classification

Domain Context

CATH Clusters

Superfamily Metalloenzyme, LuxS/M16 peptidase-like
Functional Family Mitochondrial-processing peptidase subunit beta, mitochondrial

Enzyme Information

3.4.24.64
Mitochondrial processing peptidase.
based on mapping to UniProt P10507
Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.
-!- Known from the mitochondrial matrix of fungi and mammals. -!- Belongs to peptidase family M16. -!- Formerly EC 3.4.99.41.

UniProtKB Entries (1)

P10507
MPPB_YEAST
Saccharomyces cerevisiae S288C
Mitochondrial-processing peptidase subunit beta

PDB Structure

PDB 1HR9
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences.
Taylor, A.B., Smith, B.S., Kitada, S., Kojima, K., Miyaura, H., Otwinowski, Z., Ito, A., Deisenhofer, J.
Structure