CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha-helical ferredoxin
Functional Family Dihydropyrimidine dehydrogenase [NADP(+)]

Enzyme Information

1.3.1.2
Dihydropyrimidine dehydrogenase (NADP(+)).
based on mapping to UniProt Q28943
5,6-dihydrouracil + NADP(+) = uracil + NADPH.
-!- Also acts on dihydrothymine.

UniProtKB Entries (1)

Q28943
DPYD_PIG
Sus scrofa
Dihydropyrimidine dehydrogenase [NADP(+)]

PDB Structure

PDB 1H7X
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Dihydropyrimidine Dehydrogenase, a Major Determinant of the Pharmacokinetics of the Anti-Cancer Drug 5-Fluorouracil
Dobritzsch, D., Schneider, G., Schnackerz, K.D., Lindqvist, Y.
Embo J.