CATH Classification

Domain Context

CATH Clusters

Superfamily Poly(ADP-ribose) polymerase, regulatory domain
Functional Family Poly [ADP-ribose] polymerase

Enzyme Information

2.4.2.30
NAD(+) ADP-ribosyltransferase.
based on mapping to UniProt O88554
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
2.4.2.-
Pentosyltransferases.
based on mapping to UniProt O88554

UniProtKB Entries (1)

O88554
PARP2_MOUSE
Mus musculus
Poly [ADP-ribose] polymerase 2

PDB Structure

PDB 1GS0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Catalytic Fragment of Murine Poly(Adp-Ribose) Polymerase-2
Oliver, A.W., Ame, J.C., Roe, S.M., Good, V., De Murcia, G., Pearl, L.H.
Nucleic Acids Res.