CATH Classification

Domain Context

CATH Clusters

Superfamily N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family UDP-glucose 6-dehydrogenase

Enzyme Information

1.1.1.22
UDP-glucose 6-dehydrogenase.
based on mapping to UniProt P0C0F4
UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH.
-!- Also acts on UDP-2-deoxyglucose.

UniProtKB Entries (1)

P0C0F4
UDG_STRPY
Streptococcus pyogenes
UDP-glucose 6-dehydrogenase

PDB Structure

PDB 1DLI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The first structure of UDP-glucose dehydrogenase reveals the catalytic residues necessary for the two-fold oxidation.
Campbell, R.E., Mosimann, S.C., van De Rijn, I., Tanner, M.E., Strynadka, N.C.
Biochemistry