CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1360.10
Functional Family Type 2 DNA topoisomerase 6 subunit A

Enzyme Information

5.6.2.3
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt Q57815
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

Q57815
TOP6A_METJA
Methanocaldococcus jannaschii DSM 2661
Type 2 DNA topoisomerase 6 subunit A

PDB Structure

PDB 1D3Y
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure and function of an archaeal topoisomerase VI subunit with homology to the meiotic recombination factor Spo11.
Nichols, M.D., DeAngelis, K., Keck, J.L., Berger, J.M.
EMBO J.