CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclophilin-like
Functional Family Peptidyl-prolyl cis-trans isomerase G

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q27450
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q27450
CYP1_BRUMA
Brugia malayi
Peptidyl-prolyl cis-trans isomerase 1

PDB Structure

PDB 1C5F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Complex of Brugia Malayi Cyclophilin and Cyclosporin A.
Ellis, P.J., Carlow, C.K., Ma, D., Kuhn, P.
Biochemistry