CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.90 | Alpha-Beta Complex | |
3.90.180 | Quinone Oxidoreductase; Chain A, domain 1 | |
3.90.180.10 | Medium-chain alcohol dehydrogenases, catalytic domain |
Domain Context
CATH Clusters
Superfamily | Medium-chain alcohol dehydrogenases, catalytic domain |
Functional Family | S-(hydroxymethyl)glutathione dehydrogenase |
Enzyme Information
1.1.1.1 |
Alcohol dehydrogenase.
based on mapping to UniProt P00327
(1) A primary alcohol + NAD(+) = an aldehyde + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
-!- Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. -!- The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
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UniProtKB Entries (1)
P00327 |
ADH1E_HORSE
Equus caballus
Alcohol dehydrogenase E chain
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PDB Structure
PDB | 1BTO |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Flexibility of liver alcohol dehydrogenase in stereoselective binding of 3-butylthiolane 1-oxides.
Biochemistry
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