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CATH Superfamily 4.10.740.10

Coagulation Factor IX

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Coagulation Factor IX
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 349: Vitamin K-dependent protein S

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Coagulation factor Xa. [EC: 3.4.21.6]
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
  • A blood coagulation factor formed from the proenzyme factor X by limited proteolysis.
  • Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds.
  • The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca(2+) and phospholipids.
  • Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va.
  • Belongs to peptidase family S1.
 16 A6MFK7 A6MFK8 B5G6G5 P25155 P81428 P82807 P83370 Q1L658 Q1L659 Q4QXT9
(6 more...)
Thrombin. [EC: 3.4.21.5]
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
  • More selective than trypsin and plasmin.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.4.13.
 9 A0A087XJA5 A0A146XRX0 A0A147AMC1 A0A1A8U6V8 D9U8F9 I3JQX8 J7M5E6 M3ZVI8 Q804W7
Coagulation factor VIIa. [EC: 3.4.21.21]
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
  • Formed from the precursor factor VII.
  • The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human.
  • Belongs to peptidase family S1.
 1 Q804X1