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CATH Superfamily 4.10.740.10

Coagulation Factor IX

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Coagulation Factor IX
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 343: Coagulation factor VII (Predicted)

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Coagulation factor Xa. [EC: 3.4.21.6]
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
  • A blood coagulation factor formed from the proenzyme factor X by limited proteolysis.
  • Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds.
  • The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca(2+) and phospholipids.
  • Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va.
  • Belongs to peptidase family S1.
 11 A0A061IQ22 A0A061IR16 A0N065 H2Q7T9 O19045 O88947 P00742 P00743 Q3TBR2 Q5JVE7
(1 more...)
Coagulation factor VIIa. [EC: 3.4.21.21]
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
  • Formed from the precursor factor VII.
  • The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human.
  • Belongs to peptidase family S1.
 9 A0A1B1PFW7 P08709 P22457 P70375 P98139 Q2F9P2 Q2F9P4 Q542C2 Q8K3U6
Protein C (activated). [EC: 3.4.21.69]
Degradation of blood coagulation factors Va and VIIIa.
  • One of the gamma-carboxyglutamic acid-containing coagulation factors.
  • Formed from protein C, the proenzyme that circulates in plasma, by the action of a complex of thrombin with thrombomodulin, or by serine endopeptidases present in several snake venoms.
  • Belongs to peptidase family S1.
 7 P00745 P04070 P31394 P33587 Q28278 Q28661 Q9GLP2
Thrombin. [EC: 3.4.21.5]
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
  • More selective than trypsin and plasmin.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.4.13.
 5 A0A060VM28 A0A060VXZ0 A0A0F8C196 B6RK59 Q5NKF9