The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Disintegrin domain
".
FunFam 1308: Disintegrin and metalloproteinase domain-containin...
There are 5 EC terms in this cluster
Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
| EC Term | Annotations | Evidence |
|---|---|---|
|
Russellysin.
[EC: 3.4.24.58]
Specifically activates several components of the blood clotting system, including coagulation factor X, coagulation factor IX and protein C by cleavage of Arg-|-Xaa bonds. Has no action on insulin B chain.
|
2 | Q7LZ61 Q7T046 |
|
Trimerelysin I.
[EC: 3.4.24.52]
Cleavage of only two bonds: 10-His-|-Leu-11 and 14-Ala-|-Leu-15, in the insulin B chain.
|
1 | E0VJV8 |
|
Jararhagin.
[EC: 3.4.24.73]
Cleavage of 10-His-|-Leu-11, 14-Ala-|-Leu-15, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 bonds in insulin B chain.
|
1 | P30431 |
|
Bothropasin.
[EC: 3.4.24.49]
Cleavage of 5-His-|-Leu-6, 10-His-|-Leu-11, 14-Ala-|-Leu-15, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 in insulin B chain.
|
1 | O93523 |
|
Atrolysin A.
[EC: 3.4.24.1]
Cleavage of 3-Asn-|-Gln-4, 5-His-|-Leu-6, 10-His-|-Leu-11, 14-Ala-|-Leu- 15 and 16-Tyr-|-Leu-17 in insulin B chain; removes C-terminal Leu from small peptides.
|
1 | Q92043 |