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CATH Superfamily 4.10.70.10

Disintegrin domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Disintegrin domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1250: Disintegrin and metallopeptidase domain 10

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
ADAM10 endopeptidase. [EC: 3.4.24.81]
Endopeptidase of broad specificity.
  • Partially responsible for the 'alpha-secretase' activity in brain that degrades the potentially harmful beta-amyloid peptide.
  • Work with ADAM10-deficient mice supports a role in Notch signaling.
  • Belongs to peptidase family M12.
 12 A0A024R5U5 A0A061I1D6 A0A0B8RTY1 B3VKE8 G1RKW3 H2Q9I4 H9EQI5 O14672 O35598 Q10741
(2 more...)