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CATH Superfamily 4.10.470.10

Ricin (A Subunit), domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Ricin (A Subunit), domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 127: Ribosome-inactivating protein saporin-6

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
RRNA N-glycosylase. [EC: 3.2.2.22]
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
  • Ricin A-chain and related toxins show this activity.
  • Naked rRNA is attacked more slowly than rRNA in intact ribosomes.
  • Naked rRNA from Escherichia coli is cleaved at a corresponding position.
 9 A6H5D1 P20656 P24476 P27559 P27560 Q2QEH3 Q41389 Q41391 Q7M1Z2