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CATH Superfamily 4.10.410.10

Pancreatic trypsin inhibitor Kunitz domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Pancreatic trypsin inhibitor Kunitz domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3410: Kunitz-type protease inhibitor 1

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Procollagen N-endopeptidase. [EC: 3.4.24.14]
Cleaves the N-propeptide of collagen chain alpha-1(I) at Pro-|-Gln and of alpha-1(II) and alpha-2(I) at Ala-|-Gln.
  • Removes N-terminal propeptides of type I and II collagens prior to fibril assembly.
  • Does not cleave type III procollagen.
  • Belongs to peptidase family M12.
 4 E0W094 E0W094 E0W094 E0W094
Arylesterase. [EC: 3.1.1.2]
A phenyl acetate + H(2)O = a phenol + acetate.
  • Acts on many phenolic esters.
  • It is likely that the three forms of human paraoxonase are lactonases rather than aromatic esterases.
  • The natural substrates of the paraoxonases are lactones, with (+-)-5- hydroxy-6E,8Z,11Z,4Z-eicostetraenoic-acid 1,5-lactone being the best substrate.
 2 E0VCJ0 E0W462
Receptor protein serine/threonine kinase. [EC: 2.7.11.30]
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
  • The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death.
  • Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase.
  • Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates.
  • Formerly EC 2.7.1.37.
 1 A0A089MX19
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