The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"GPCR, family 2, extracellular hormone receptor domain
".
FunFam 525: Growth hormone-releasing hormone receptor
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
G-protein coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
1 | Q02643 (/IC) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q02643 (/IPI) |
Growth hormone-releasing hormone receptor activity GO:0016520
Combining with growth hormone-releasing hormone to initiate a change in cell activity.
|
1 | Q02643 (/IMP) |
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
|
1 | Q02643 (/IPI) |
Growth factor binding GO:0019838
Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
|
1 | Q02643 (/IPI) |
There are 11 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
|
1 | Q02643 (/IDA) |
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | Q02643 (/IDA) |
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
|
1 | Q02643 (/IMP) |
Positive regulation of cAMP biosynthetic process GO:0030819
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
|
1 | Q02643 (/IDA) |
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
1 | Q02643 (/IMP) |
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
|
1 | Q02643 (/IMP) |
Positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568
Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling.
|
1 | Q02643 (/NAS) |
Response to estrogen GO:0043627
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
|
1 | Q02643 (/IDA) |
Multicellular organismal reproductive process GO:0048609
The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.
|
1 | Q02643 (/NAS) |
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
|
1 | Q02643 (/IDA) |
Positive regulation of growth hormone secretion GO:0060124
Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell.
|
1 | Q02643 (/NAS) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nuclear inner membrane GO:0005637
The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.
|
1 | Q02643 (/IDA) |
Nuclear outer membrane GO:0005640
The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.
|
1 | Q02643 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q02643 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q02643 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q02643 (/TAS) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | Q02643 (/IDA) |
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q02643 (/IDA) |
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
|
1 | Q02643 (/IDA) |
Secretory granule GO:0030141
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
|
1 | Q02643 (/IDA) |