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CATH Superfamily 3.90.79.10

Nucleoside Triphosphate Pyrophosphohydrolase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Nucleoside Triphosphate Pyrophosphohydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 21691: Isopentenyl-diphosphate delta-isomerase, type 1

There are 10 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Isopentenyl-diphosphate Delta-isomerase. [EC: 5.3.3.2]
Isopentenyl diphosphate = dimethylallyl diphosphate.
    		 5184 A0A010Q3L4 A0A010Q3L4 A0A010YGC9 A0A010YGC9 A0A011SK67 A0A011SK67 A0A014M5W9 A0A014M5W9 A0A014NWA7 A0A014NWA7
    (5174 more...)
    8-oxo-dGTP diphosphatase. [EC: 3.6.1.55]
    8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.
    • This enzyme hydrolyzes the phosphoanhydride bond between the alpha and beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA.
    • It does not hydrolyze 2-hydroxy-dATP (cf. EC 3.6.1.56).
    		 58 A0A0F0CLU4 A0A0F0CLU4 A0A0M6WHC4 A0A0M6WHC4 A0A0U5PIU2 A0A0U5PIU2 A0A173RRF6 A0A173RRF6 A0A173SLQ0 A0A173SLQ0
    (48 more...)
    16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase. [EC: 2.1.1.182]
    4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)- dimethyladenine(1519) in 16S rRNA.
    • KsgA introduces the most highly conserved ribosomal RNA modification, the dimethylation of adenine(1518) and adenine(1519) in 16S rRNA.
    • Strains lacking the methylase are resistant to kasugamycin.
    • Formerly EC 2.1.1.48.
    		 20 A0A139TR72 A0A139TR72 A0A146G1H8 A0A146G1H8 A0A1C7HC08 A0A1C7HC08 A0A1C7PEV3 A0A1C7PEV3 A0A1G3ZDG1 A0A1G3ZDG1
    (10 more...)
    Nucleoside diphosphate phosphatase. [EC: 3.6.1.6]
    A nucleoside diphosphate + H(2)O = a nucleoside phosphate + phosphate.
    • The enzyme, which appears to be limited to metazoa, acts on multiple nucleoside diphosphates as well as on D-ribose 5-diphosphate.
    • Specificity depends on species and isoform.
    		 20 A0A024VJJ4 A0A024VJJ4 A0A060RXS5 A0A060RXS5 A0A0L7KD60 A0A0L7KD60 A0A0L7M4Q2 A0A0L7M4Q2 Q8IDK8 Q8IDK8
    (10 more...)
    Dimethylallyltranstransferase. [EC: 2.5.1.1]
    Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
    • Will not accept larger prenyl diphosphates as efficient donors.
    		 6 A0A075HBX0 A0A075HBX0 A0A075I569 A0A075I569 A0A075I6S9 A0A075I6S9
    Glycerate dehydrogenase. [EC: 1.1.1.29]
    D-glycerate + NAD(+) = hydroxypyruvate + NADH.
      		 4 A0A1C5NXL0 A0A1C5NXL0 A0A1C6BMD5 A0A1C6BMD5
      Lipoyl synthase. [EC: 2.8.1.8]
      Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl- L-methionine + 2 reduced [2Fe-2S] ferredoxin = protein N(6)- (lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin.
      • Member of the 'AdoMet radical' (radical SAM) family, all members of which produce the 5'-deoxyadenosin-5'-yl radical and methionine from AdoMet (i.e. S-adenosylmethionine, or S-(5'-deoxyadenosin- 5'-yl)methionine), by the addition of an electron from an iron-sulfur center.
      • The radical is converted into 5'-deoxyadenosine when it abstracts a hydrogen atom from C-6 and C-8, leaving reactive radicals at these positions so that they can add sulfur, with inversion of configuration.
      • Catalyzes the final step in the de-novo biosynthesis of the lipoyl cofactor, with the other enzyme involved being EC 2.3.1.181.
      • Lipoylation is essential for the function of several key enzymes involved in oxidative metabolism, as it converts apoprotein into the biologically active holoprotein.
      • Examples of such lipoylated proteins include pyruvate dehydrogenase (E(2) domain), 2-oxoglutarate dehydrogenase (E(2) domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein).
      • An alternative lipoylation pathway involves EC 2.7.7.63, which can lipoylate apoproteins using exogenous lipoic acid (or its analogs).
      		 2 A0A1L0C1P8 A0A1L0C1P8
      Hydroxymethylglutaryl-CoA reductase (NADPH). [EC: 1.1.1.34]
      (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.
      • The enzyme is inactivated by EC 2.7.11.31 and reactivated by EC 3.1.3.47.
      		 2 A0A0L9SZB4 A0A0L9SZB4
      Tagatose-6-phosphate kinase. [EC: 2.7.1.144]
      ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate.
        		 2 A0A1C5KR64 A0A1C5KR64
        DNA topoisomerase. [EC: 5.99.1.2]
        ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
        • Brings about the conversion of one topological isomer of DNA into another, e.g. the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences (cf. EC 5.99.1.3).
        		 2 C5LAZ3 C5LAZ3
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