The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Nucleoside Triphosphate Pyrophosphohydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 21682: Bifunctional NMN adenylyltransferase/Nudix hydrola...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
ADP-ribose diphosphatase. [EC: 3.6.1.13]
ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate.
    6 A0A068N1U1 A0A068N1U1 F6BCY5 F6BCY5 Q58549 Q58549
    Nicotinamide-nucleotide adenylyltransferase. [EC: 2.7.7.1]
    ATP + nicotinamide ribonucleotide = diphosphate + NAD(+).
    • Nicotinate nucleotide can also act as acceptor.
    • See also EC 2.7.7.18.
    6 A0A068N1U1 A0A068N1U1 L8AQK4 L8AQK4 Q55928 Q55928
    (d)CTP diphosphatase. [EC: 3.6.1.65]
    (1) CTP + H(2)O = CMP + diphosphate. (2) dCTP + H(2)O = dCMP + diphosphate.
    • The enzyme, characterized from the bacterium Escherichia coli, is specific for the pyrimidine nucleotides CTP and dCTP.
    • It also acts on 5-methyl-dCTP, 5-hydroxy-dCTP and 8-hydroxy-dGTP.
    2 A0A1D8G0F3 A0A1D8G0F3
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