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CATH Superfamily 3.90.79.10

Nucleoside Triphosphate Pyrophosphohydrolase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Nucleoside Triphosphate Pyrophosphohydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 21641: Probable 8-oxo-dGTP diphosphatase NUDT15

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Nucleotide diphosphatase. [EC: 3.6.1.9]
A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate.
  • The enzyme preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates.
  • In vitro the enzyme also acts as a nucleotidohydrolase on ADP, NAD(+), NADP(+), FAD, and CoA.
  • Formerly EC 3.6.1.19.
 8 G3QYV1 G3QYV1 H2Q7J8 H2Q7J8 Q8BG93 Q8BG93 Q9NV35 Q9NV35
NAD(+) diphosphatase. [EC: 3.6.1.22]
NAD(H) + H(2)O = AMP + NMN(H).
  • This enzyme, described from plants, animals, and bacteria, can act on both reduced and oxidized forms of its substrate, although enzymes from different organisms have different preferences.
  • Also acts on other dinucleotides, including NADP(H), FAD(H(2)), and the thionicotinamide analogs of NAD(+) and NADP(+).
 4 A0A178WE57 A0A178WE57 Q9CA40 Q9CA40
8-oxo-dGTP diphosphatase. [EC: 3.6.1.55]
8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.
  • This enzyme hydrolyzes the phosphoanhydride bond between the alpha and beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA.
  • It does not hydrolyze 2-hydroxy-dATP (cf. EC 3.6.1.56).
 4 A0A178WE57 A0A178WE57 Q9CA40 Q9CA40
Dihydroneopterin triphosphate diphosphatase. [EC: 3.6.1.67]
7,8-dihydroneopterin 3'-triphosphate + H(2)O = 7,8-dihydroneopterin 3'-phosphate + diphosphate.
  • The enzyme participates in a folate biosynthesis pathway, which is found in bacteria, fungi, and plants.
  • Formerly EC 3.6.1.n4.
 4 A0A178WE57 A0A178WE57 Q9CA40 Q9CA40
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