The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Nucleoside Triphosphate Pyrophosphohydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 21515: Nucleoside triphosphatase NudI

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Nucleotide diphosphatase. [EC: 3.6.1.9]
A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate.
  • The enzyme preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates.
  • In vitro the enzyme also acts as a nucleotidohydrolase on ADP, NAD(+), NADP(+), FAD, and CoA.
  • Formerly EC 3.6.1.19.
882 A0A017IFC8 A0A017IFC8 A0A023VEE5 A0A023VEE5 A0A023Z0W8 A0A023Z0W8 A0A024KXY3 A0A024KXY3 A0A024L1H8 A0A024L1H8
(872 more...)
DCTP diphosphatase. [EC: 3.6.1.12]
dCTP + H(2)O = dCMP + diphosphate.
  • Also hydrolyzes dCDP to dCMP and phosphate.
882 A0A017IFC8 A0A017IFC8 A0A023VEE5 A0A023VEE5 A0A023Z0W8 A0A023Z0W8 A0A024KXY3 A0A024KXY3 A0A024L1H8 A0A024L1H8
(872 more...)
DUTP diphosphatase. [EC: 3.6.1.23]
dUTP + H(2)O = dUMP + diphosphate.
    882 A0A017IFC8 A0A017IFC8 A0A023VEE5 A0A023VEE5 A0A023Z0W8 A0A023Z0W8 A0A024KXY3 A0A024KXY3 A0A024L1H8 A0A024L1H8
    (872 more...)
    ADP-ribose diphosphatase. [EC: 3.6.1.13]
    ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate.
      2 A0A0W8JDV2 A0A0W8JDV2
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