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CATH Superfamily 3.90.79.10

Nucleoside Triphosphate Pyrophosphohydrolase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Nucleoside Triphosphate Pyrophosphohydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 21430: Diphosphoinositol polyphosphate phosphohydrolase 1

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Diphosphoinositol-polyphosphate diphosphatase. [EC: 3.6.1.52]
Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate.
  • This enzyme hydrolyzes the diphosphate bond, leaving a phospho group where a diphospho group had been.
  • It can also act on bis(adenosine) diphosphate.
 64 A0A024RBD0 A0A024RBD0 A0A096N9R1 A0A096N9R1 A0A0D9RBP5 A0A0D9RBP5 A0A0D9RJT5 A0A0D9RJT5 A0A1D5Q801 A0A1D5Q801
(54 more...)
Diadenosine hexaphosphate hydrolase (AMP-forming). [EC: 3.6.1.60]
(1) P(1),P(6)-bis(5'-adenosyl)hexaphosphate + H(2)O = adenosine 5'-pentaphosphate + AMP. (2) P(1),P(5)-bis(5'-adenosyl)pentaphosphate + H(2)O = adenosine 5'-tetraphosphate + AMP.
  • A divalent cation is essential for activity.
  • Mn(2+) (2-6 mM) is most effective.
  • The enzyme controls intracellular levels of P(1),P(5)- bis(5'-adenosyl)pentaphosphate and P(1),P(6)- bis(5'-adenosyl)hexaphosphate.
  • Weak activity with P(1),P(4)-bis(5'-adenosyl)tetraphosphate.
  • Marked preference for adenine over guanine nucleotides.
 30 A0A096N9R1 A0A096N9R1 A0A0D9RJT5 A0A0D9RJT5 A0A1D5Q801 A0A1D5Q801 D3ZYH3 D3ZYH3 G1R9R0 G1R9R0
(20 more...)
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