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CATH Superfamily 3.90.780.10

5'-Nucleotidase, C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
5'-Nucleotidase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2221: NAD nucleotidase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
5'-nucleotidase. [EC: 3.1.3.5]
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
  • Wide specificity for 5'-nucleotides.
 23 A0A0A7X3M7 A0A0B7GVV9 A0A0C5EU83 A0A0E1WKM1 A0A0H3BJS5 A0A0H3PC20 A0A0Y0E7C1 A0A112WSA1 A0A121YHQ4 A0A1L7DG18
(13 more...)
UDP-sugar diphosphatase. [EC: 3.6.1.45]
UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate.
  • UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities.
  • Thus, this enzyme has a specificity distinct from that of EC 3.6.1.21.
  • Some but not all enzymes of this class also appear to have EC 3.1.3.5 activity.
 7 A0A0A7X3M7 A0A0H3BJS5 A0A1L7DG18 F7XRU6 H6KUF3 O83142 R9UVN3
NAD(+) diphosphatase. [EC: 3.6.1.22]
NAD(H) + H(2)O = AMP + NMN(H).
  • This enzyme, described from plants, animals, and bacteria, can act on both reduced and oxidized forms of its substrate, although enzymes from different organisms have different preferences.
  • Also acts on other dinucleotides, including NADP(H), FAD(H(2)), and the thionicotinamide analogs of NAD(+) and NADP(+).
 3 E7NWL2 F0ERY6 I3DBV4