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CATH Superfamily 3.90.780.10

5'-Nucleotidase, C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
5'-Nucleotidase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2219: Trifunctional nucleotide phosphoesterase protein

There are 11 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
5'-nucleotidase. [EC: 3.1.3.5]
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
  • Wide specificity for 5'-nucleotides.
 939 A0A011NBB2 A0A014M0N3 A0A017HCR8 A0A017HNX5 A0A017IKC5 A0A022PR38 A0A023V9J5 A0A023YTA9 A0A024K834 A0A025CFP8
(929 more...)
UDP-sugar diphosphatase. [EC: 3.6.1.45]
UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate.
  • UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities.
  • Thus, this enzyme has a specificity distinct from that of EC 3.6.1.21.
  • Some but not all enzymes of this class also appear to have EC 3.1.3.5 activity.
 728 A0A011NBB2 A0A014M0N3 A0A022PR38 A0A023V9J5 A0A023YTA9 A0A024KRP5 A0A025CFP8 A0A026RWJ0 A0A026UGI6 A0A027TLF9
(718 more...)
2',3'-cyclic-nucleotide 2'-phosphodiesterase. [EC: 3.1.4.16]
Nucleoside 2',3'-cyclic phosphate + H(2)O = nucleoside 3'-phosphate.
  • Also hydrolyzes 3'-nucleoside monophosphates and bis-4-nitrophenyl phosphate, but not 3'-deoxynucleotides.
  • Similar reactions are carried out by EC 3.1.27.3 and EC 3.1.27.5.
 53 A0A081L8Q1 A0A084GJP5 A0A084GL40 A0A0A0TUE0 A0A0B4S5B2 A0A0C2VP72 A0A0D7XF00 A0A0D7XSB1 A0A0E1LKE4 A0A0H1RVC9
(43 more...)
3'-nucleotidase. [EC: 3.1.3.6]
A 3'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
  • Wide specificity for 3'-nucleotides.
 44 A0A081L8Q1 A0A084GJP5 A0A084GL40 A0A0A0TUE0 A0A0B4S5B2 A0A0D7XF00 A0A0D7XSB1 A0A0E1LKE4 A0A0H1RVC9 A0A0J1I7A1
(34 more...)
Apyrase. [EC: 3.6.1.5]
A nucleoside 5'-triphosphate + 2 H(2)O = a nucleoside 5'-phosphate + 2 phosphate.
  • Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates.
  • They differ from ATPases, which specifically hydrolyze ATP, by hydrolyzing both ATP and ADP.
  • Most of the ecto-ATPases that occur on the cell surface and hydrolyze extracellular nucleotides belong to this enzyme family.
 6 A0A0F8DFE2 B3A0N5 E0D877 F1JZ10 P50635 Q70GK8
[Myosin-light-chain] phosphatase. [EC: 3.1.3.53]
[Myosin light-chain] phosphate + H(2)O = [myosin light-chain] + phosphate.
  • Composed of three subunits.
  • The holoenzyme dephosphorylates myosin light chains and EC 2.7.11.31, but not myosin; the catalytic subunit acts on all three substrates.
 5 A0A0S4QBT3 A3N0D1 B3GXM3 D9PE44 E0FMA2
Deleted entry. [EC: 3.1.2.15]
    		1 W6VZI7
    Ribonuclease P. [EC: 3.1.26.5]
    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
    • Essential for tRNA processing; generates 5'-termini of mature tRNA molecules.
    		 1 A0A0C2VGD2
    Nucleotidase. [EC: 3.1.3.31]
    A nucleotide + H(2)O = a nucleoside + phosphate.
    • A wide specificity for 2', 3'- and 5'- nucleotides; also hydrolyzes glycerol phosphate and 4-nitrophenyl phosphate.
    • Formerly EC 3.1.3.30.
    		 1 M5RLN7
    Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
    NTP + H(2)O = NDP + phosphate.
    • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
    • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
    • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
    		 1 Q9VZ33
    Nucleoside diphosphate phosphatase. [EC: 3.6.1.6]
    A nucleoside diphosphate + H(2)O = a nucleoside phosphate + phosphate.
    • The enzyme, which appears to be limited to metazoa, acts on multiple nucleoside diphosphates as well as on D-ribose 5-diphosphate.
    • Specificity depends on species and isoform.
    		 1 Q9VZ33