View in Gene3D

CATH Superfamily 3.90.70.10

Cysteine proteinases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cysteine proteinases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 17093: Ubiquitin carboxyl-terminal hydrolase 22

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Ubiquitinyl hydrolase 1. [EC: 3.4.19.12]
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
  • Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides.
  • Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals.
  • Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde).
  • Belongs to peptidase family C12.
 476 A0A022R5R2 A0A023EYZ7 A0A023GKS9 A0A026X152 A0A034VBS3 A0A044RAK7 A0A059CWR1 A0A060XHV5 A0A061GMZ9 A0A061GQ99
(466 more...)
Deleted entry. [EC: 3.1.2.15]
    		2 B9RNQ1 B9SU52
    Phosphomannomutase. [EC: 5.4.2.8]
    Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
    • Alpha-D-mannose 1,6-bisphosphate or alpha-D-glucose 1,6-bisphosphate can act as cofactor.
    • Formerly EC 2.7.5.7.
    		 1 A0A0D2M9Q3
    CATH-Gene3D is a Global Biodata Core Resource Learn more...