View in Gene3D

CATH Superfamily 3.90.70.10

Cysteine proteinases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cysteine proteinases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 16984: Ubiquitin carboxyl-terminal hydrolase creB

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Ubiquitinyl hydrolase 1. [EC: 3.4.19.12]
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
  • Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides.
  • Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals.
  • Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde).
  • Belongs to peptidase family C12.
 108 A0A061IJI0 A0A061IJI0 A0A061IMH6 A0A061IMH6 A0A096ND90 A0A096ND90 A0A096NYM6 A0A096NYM6 A0A0D9QY46 A0A0D9QY46
(98 more...)
Deleted entry. [EC: 3.1.2.15]
    		12 B7Q0N0 B7Q0N0 B9SZ50 B9SZ50 B9WAF1 B9WAF1 E0VDQ1 E0VDQ1 K0KX19 K0KX19
    (2 more...)
    CATH-Gene3D is a Global Biodata Core Resource Learn more...