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CATH Superfamily 3.90.70.10

Cysteine proteinases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cysteine proteinases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16963: Aminopeptidase C (Bleomycin hydrolase)

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Bleomycin hydrolase. [EC: 3.4.22.40]
Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.
  • The active sites are on the walls of a central channel through the molecule, and access of substrate molecules to them is obstructed by this and by the C-terminus of each polypeptide chain.
  • Bleomycin can scarcely be the natural substrate, and there are reports of limited endopeptidase activity.
  • Known from bacteria as well as eukaryotic organisms.
  • Hydrolase H from chicken muscle has many similarities to bleomycin hydrolase, but hydrolyzes Ph-CO-Arg-2-naphthylamine as well as aminopeptidase substrates.
  • Belongs to peptidase family C1.
 746 A0A011RPB2 A0A015WIP7 A0A016AK27 A0A016H8Q2 A0A016HZG0 A0A017NT79 A0A059N5K4 A0A061CIK8 A0A061CKH3 A0A062XLI1
(736 more...)
Dipeptidyl-peptidase I. [EC: 3.4.14.1]
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.
  • Also polymerizes dipeptide amides, arylamides and esters at neutral pH.
  • Cl(-)-dependent lysosomal cysteine-type peptidase.
  • Belongs to peptidase family C1.
  • Formerly EC 3.4.4.9.
 3 A0A1C2CCK9 C5WII0 M4YZF4