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CATH Superfamily 3.90.550.10

Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 63973: Chondroitin synthase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase. [EC: 2.4.1.226]
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D- glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl- beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan.
  • Involved in the biosynthesis of chondroitin and dermatan sulfate.
  • The human chondroitin synthetase is a bifunctional glycosyltransferase, which also has the EC 2.4.1.175 activity required for the synthesis of the chondroitin sulfate disaccharide repeats.
  • Similar chondroitin synthase 'copolymerases' can be found in Pasteurella multocida and Escherichia coli.
  • There is also another human protein with apparently only the 3-beta- glucuronosyltransferase activity.
 24 A0A069XXT2 A0A069XXT2 A0A073H5N7 A0A073H5N7 A0A073UQL6 A0A073UQL6 A0A1D7R1M1 A0A1D7R1M1 A0A1J5K9G2 A0A1J5K9G2
(14 more...)
Hyaluronan synthase. [EC: 2.4.1.212]
(1) UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N- acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl- beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D- glucosaminyl-(1->4)-(nascent hyaluronan). (2) UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D- glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl- (1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)- (nascent hyaluronan).
  • Adds GlcNAc to nascent hyaluronan when the non-reducing end is GlcA, but it adds GlcA when the non-reducing end is GlcNAc.
  • Highly specific for UDP-GlcNAc and UDP-GlcA; no copolymerization is observed if either is replaced by UDP-Glc, UDP-Gal, UDP-GalNAc or UDP-GalA.
 8 A0A1D7R1M1 A0A1D7R1M1 A0A1J5K9G2 A0A1J5K9G2 Q7BLV3 Q7BLV3 V4ND04 V4ND04
Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N- acetylgalactosaminyltransferase. [EC: 2.4.1.175]
UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl- beta-D-galactosaminyl-proteoglycan = UDP + N-acetyl-beta-D- galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D- galactosaminyl-proteoglycan.
  • Involved in the biosynthesis of chondroitin sulfate.
  • The human form of this enzyme is a bifunctional glycosyltransferase, which also has the EC 2.4.1.226 activity required for the synthesis of the chondroitin sulfate disaccharide repeats.
  • Similar chondroitin synthase 'copolymerases' can be found in Pasteurella multocida and Escherichia coli.
 8 Q8L0V4 Q8L0V4 Q9CMP0 Q9CMP0 T9CKI5 T9CKI5 V8JXL1 V8JXL1