The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 521: Aromatic-ring-hydroxylating dioxygenase, alpha sub...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Anthranilate 1,2-dioxygenase (deaminating, decarboxylating). [EC: 1.14.12.1]
Anthranilate + NAD(P)H + O(2) = catechol + CO(2) + NAD(P)(+) + NH(3).
    6 A0A0H5LZD2 A0A124U544 A0A1K1TGG8 B1H857 I2DU94 Q84BZ3
    Benzoate 1,2-dioxygenase. [EC: 1.14.12.10]
    Benzoate + NADH + O(2) = (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1- carboxylate + NAD(+).
    • A system, containing a reductase which is an iron-sulfur flavoprotein (FAD), and an iron-sulfur oxygenase.
    • Formerly EC 1.13.99.2.
    2 A0A063BGG4 W6WBZ4
    Biphenyl 2,3-dioxygenase. [EC: 1.14.12.18]
    Biphenyl + NADH + O(2) = (1S,2R)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+).
    • The enzyme from Burkholderia fungorum strain LB400 (previously Pseudomonas sp.) is part of a multicomponent system composed of an NADH:ferredoxin oxidoreductase (FAD cofactor), a [2Fe-2S] Rieske-type ferredoxin, and a terminal oxygenase that contains a [2Fe-2S] Rieske- type iron-sulfur cluster and a catalytic mononuclear nonheme iron center.
    • Chlorine-substituted biphenyls can also act as substrates.
    • Similar to the three-component enzyme systems EC 1.14.12.3 and EC 1.14.12.11.
    1 Q393D0
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