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CATH Superfamily 3.90.380.10

Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2091: Benzoate 1,2-dioxygenase alpha subunit

There are 12 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-phenylpropanoate dioxygenase. [EC: 1.14.12.19]
(1) 3-phenylpropanoate + NADH + O(2) = 3-(cis-5,6-dihydroxycyclohexa-1,3- dien-1-yl)propanoate + NAD(+). (2) (2E)-3-phenylprop-2-enoate + NADH + O(2) = (2E)-3-(2,3- dihydroxyphenyl)prop-2-enoate + NAD(+).
  • This enzyme catalyzes a step in the pathway of phenylpropanoid compounds degradation.
  • It catalyzes the insertion of both atoms of molecular oxygen into positions 2 and 3 of the phenyl ring of 3-phenylpropanoate or (2E)-3- phenylprop-2-enoate.
 299 A0A022PNS5 A0A023VGT2 A0A023Z0X1 A0A024KXR4 A0A025CJ25 A0A026RY39 A0A026UK62 A0A027TYM0 A0A028ASE5 A0A028E2L6
(289 more...)
Benzoate 1,2-dioxygenase. [EC: 1.14.12.10]
Benzoate + NADH + O(2) = (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1- carboxylate + NAD(+).
  • A system, containing a reductase which is an iron-sulfur flavoprotein (FAD), and an iron-sulfur oxygenase.
  • Formerly EC 1.13.99.2.
 255 A0A009EUV4 A0A009GDK5 A0A009GW66 A0A009I1G6 A0A009II34 A0A009JL91 A0A009K7I6 A0A009KTM6 A0A009NHM9 A0A009PAZ7
(245 more...)
Biphenyl 2,3-dioxygenase. [EC: 1.14.12.18]
Biphenyl + NADH + O(2) = (1S,2R)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+).
  • The enzyme from Burkholderia fungorum strain LB400 (previously Pseudomonas sp.) is part of a multicomponent system composed of an NADH:ferredoxin oxidoreductase (FAD cofactor), a [2Fe-2S] Rieske-type ferredoxin, and a terminal oxygenase that contains a [2Fe-2S] Rieske- type iron-sulfur cluster and a catalytic mononuclear nonheme iron center.
  • Chlorine-substituted biphenyls can also act as substrates.
  • Similar to the three-component enzyme systems EC 1.14.12.3 and EC 1.14.12.11.
 212 A0A009FNX5 A0A009JR72 A0A023Z0X1 A0A024KXR4 A0A025CJ25 A0A026RY39 A0A026UK62 A0A027TYM0 A0A028ASE5 A0A028E2L6
(202 more...)
Anthranilate 1,2-dioxygenase (deaminating, decarboxylating). [EC: 1.14.12.1]
Anthranilate + NAD(P)H + O(2) = catechol + CO(2) + NAD(P)(+) + NH(3).
    		 147 A0A009FZG6 A0A009G442 A0A009H5P1 A0A009IKQ7 A0A009JDA7 A0A009KFM3 A0A009LVU7 A0A009NMT3 A0A009Q5J0 A0A009QWY8
    (137 more...)
    2-halobenzoate 1,2-dioxygenase. [EC: 1.14.12.13]
    A 2-halobenzoate + NADH + O(2) = catechol + a halide anion + NAD(+) + CO(2).
    • A multicomponent enzyme system composed of a dioxygenase component and an electron transfer component.
    • The latter contains FAD.
    • The enzyme, characterized from the bacterium Burkholderia cepacia 2CBS, has a broad substrate specificity.
    • Substrates include 2-fluorobenzoate, 2-chlorobenzoate, 2-bromobenzoate, and 2-iodobenzoate, which are processed in this order of preference.
    		 110 A0A009JL91 A0A021XA10 A0A060V0W4 A0A063B9X6 A0A069BF16 A0A081YFM4 A0A084YX99 A0A088TPE9 A0A088UGD6 A0A095EKA5
    (100 more...)
    Toluene dioxygenase. [EC: 1.14.12.11]
    Toluene + NADH + O(2) = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+).
    • A system, containing a reductase which is an iron-sulfur flavoprotein (FAD), an iron-sulfur oxygenase, and a ferredoxin.
    • Some other aromatic compounds, including ethylbenzene, 4-xylene and some halogenated toluenes, are converted into the corresponding cis- dihydrodiols.
    		 13 A0A1H0T4T6 A5W4F2 C8TAG9 F2KHH4 I4K219 I4KKF1 I7B4T5 J2YH32 P0C618 Q3LUX4
    (3 more...)
    Benzene 1,2-dioxygenase. [EC: 1.14.12.3]
    Benzene + NADH + O(2) = cis-cyclohexa-3,5-diene-1,2-diol + NAD(+).
    • A system, containing a reductase which is an iron-sulfur flavoprotein (FAD), an iron-sulfur oxygenase and ferredoxin.
    		 12 A0A0A8J2Y4 A0A120LU49 A5HFU4 A5W4F2 I7B4T5 P0C618 Q07944 Q3LWS6 Q588I9 Q8VQU6
    (2 more...)
    Aminomethyltransferase. [EC: 2.1.2.10]
    [Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH(3).
    • A component, with EC 1.4.4.2 and EC 1.8.1.4, of the glycine cleavage system, formerly known as glycine synthase.
    • The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.
    		 1 G8Q212
    Naphthalene 1,2-dioxygenase. [EC: 1.14.12.12]
    Naphthalene + NADH + O(2) = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+).
    • Comprises a multicomponent system, containing a reductase that is an iron-sulfur flavoprotein (FAD; EC 1.18.1.3), an iron-sulfur oxygenase, and ferredoxin.
    		 1 A0A1I9VZ39
    2-hydroxy-3-oxopropionate reductase. [EC: 1.1.1.60]
    D-glycerate + NAD(P)(+) = 2-hydroxy-3-oxopropanoate + NAD(P)H.
      		 1 G8Q212
      3-hydroxyisobutyrate dehydrogenase. [EC: 1.1.1.31]
      3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH.
        		 1 G8Q212
        Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating). [EC: 1.1.1.44]
        6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.
        • The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions.
        • Highly specific for NADP(+).
        • Cf. EC 1.1.1.343.
        		 1 G8Q212