The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Protein tyrosine phosphatase superfamily
".
FunFam 10033: Myotubularin 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 18 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Phosphatidylinositol-3-phosphatase activity GO:0004438
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.
|
3 | A6QLT4 (/ISS) Q5R9S3 (/ISS) Q9Z2C5 (/ISS) |
|
Phosphoprotein phosphatase activity GO:0004721
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
|
3 | A6QLT4 (/ISS) Q5R9S3 (/ISS) Q9Z2C5 (/ISS) |
|
Intermediate filament binding GO:0019215
Interacting selectively and non-covalently with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space.
|
3 | A6QLT4 (/ISS) Q5R9S3 (/ISS) Q9Z2C5 (/ISS) |
|
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
|
3 | A6QLT4 (/ISS) Q5R9S3 (/ISS) Q9Z2C5 (/ISS) |
|
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity GO:0052629
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+.
|
3 | A6QLT4 (/ISS) Q5R9S3 (/ISS) Q9Z2C5 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q13496 (/IPI) Q9Z2C5 (/IPI) |
|
Phosphatidylinositol-3-phosphatase activity GO:0004438
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.
|
1 | Q13496 (/IDA) |
|
Phosphatidylinositol-3-phosphatase activity GO:0004438
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.
|
1 | Q9Z2C5 (/ISO) |
|
Phosphatidylinositol-3-phosphatase activity GO:0004438
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.
|
1 | Q13496 (/TAS) |
|
Phosphoprotein phosphatase activity GO:0004721
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
|
1 | Q13496 (/IDA) |
|
Phosphoprotein phosphatase activity GO:0004721
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
|
1 | Q9Z2C5 (/ISO) |
|
Intermediate filament binding GO:0019215
Interacting selectively and non-covalently with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space.
|
1 | Q13496 (/IDA) |
|
Intermediate filament binding GO:0019215
Interacting selectively and non-covalently with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space.
|
1 | Q9Z2C5 (/ISO) |
|
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
|
1 | Q13496 (/IDA) |
|
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
|
1 | Q9Z2C5 (/ISO) |
|
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity GO:0052629
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+.
|
1 | Q13496 (/IDA) |
|
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity GO:0052629
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+.
|
1 | Q9Z2C5 (/ISO) |
|
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity GO:0052629
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+.
|
1 | Q13496 (/TAS) |
There are 37 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
|
3 | A6QLT4 (/ISS) Q5R9S3 (/ISS) Q9Z2C5 (/ISS) |
|
Endosome to lysosome transport GO:0008333
The directed movement of substances from endosomes to lysosomes.
|
3 | A6QLT4 (/ISS) Q5R9S3 (/ISS) Q9Z2C5 (/ISS) |
|
Regulation of vacuole organization GO:0044088
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.
|
3 | A6QLT4 (/ISS) Q5R9S3 (/ISS) Q9Z2C5 (/ISS) |
|
Intermediate filament organization GO:0045109
Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
|
3 | A6QLT4 (/ISS) Q5R9S3 (/ISS) Q9Z2C5 (/ISS) |
|
Phosphatidylinositol dephosphorylation GO:0046856
The process of removing one or more phosphate groups from a phosphatidylinositol.
|
3 | A6QLT4 (/ISS) Q5R9S3 (/ISS) Q9Z2C5 (/ISS) |
|
Somatic muscle development GO:0007525
The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle.
|
2 | A0A0R4IST5 (/IMP) F8W5H1 (/IMP) |
|
Neuromuscular junction development GO:0007528
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
|
2 | A0A0R4IST5 (/IMP) F8W5H1 (/IMP) |
|
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
|
2 | A0A0R4IST5 (/IMP) F8W5H1 (/IMP) |
|
Regulation of autophagy GO:0010506
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
2 | A0A0R4IST5 (/IGI) F8W5H1 (/IGI) |
|
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
|
2 | A0A0R4IST5 (/IGI) F8W5H1 (/IGI) |
|
Muscle cell cellular homeostasis GO:0046716
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
|
2 | A0A0R4IST5 (/IGI) F8W5H1 (/IGI) |
|
Mitochondrion distribution GO:0048311
Any process that establishes the spatial arrangement of mitochondria between and within cells.
|
2 | Q13496 (/IMP) Q9Z2C5 (/IMP) |
|
Mitochondrion distribution GO:0048311
Any process that establishes the spatial arrangement of mitochondria between and within cells.
|
2 | A6QLT4 (/ISS) Q5R9S3 (/ISS) |
|
Skeletal muscle fiber development GO:0048741
The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
|
2 | A0A0R4IST5 (/IGI) F8W5H1 (/IGI) |
|
Skeletal muscle fiber development GO:0048741
The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
|
2 | A0A0R4IST5 (/IMP) F8W5H1 (/IMP) |
|
Mitochondrion morphogenesis GO:0070584
The process in which the anatomical structures of a mitochondrion are generated and organized.
|
2 | A6QLT4 (/ISS) Q5R9S3 (/ISS) |
|
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
|
1 | Q13496 (/IDA) |
|
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
|
1 | Q9Z2C5 (/ISO) |
|
Phosphatidylinositol biosynthetic process GO:0006661
The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
|
1 | Q13496 (/TAS) |
|
Endosome to lysosome transport GO:0008333
The directed movement of substances from endosomes to lysosomes.
|
1 | Q13496 (/IDA) |
|
Endosome to lysosome transport GO:0008333
The directed movement of substances from endosomes to lysosomes.
|
1 | Q9Z2C5 (/ISO) |
|
Negative regulation of TOR signaling GO:0032007
Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
|
1 | Q9Z2C5 (/IMP) |
|
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435
Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
1 | Q9Z2C5 (/IMP) |
|
Regulation of vacuole organization GO:0044088
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.
|
1 | Q13496 (/IDA) |
|
Regulation of vacuole organization GO:0044088
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.
|
1 | Q9Z2C5 (/ISO) |
|
Intermediate filament organization GO:0045109
Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
|
1 | Q13496 (/IMP) |
|
Intermediate filament organization GO:0045109
Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
|
1 | Q9Z2C5 (/ISO) |
|
Muscle cell cellular homeostasis GO:0046716
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
|
1 | Q9Z2C5 (/IMP) |
|
Phosphatidylinositol dephosphorylation GO:0046856
The process of removing one or more phosphate groups from a phosphatidylinositol.
|
1 | Q13496 (/IDA) |
|
Phosphatidylinositol dephosphorylation GO:0046856
The process of removing one or more phosphate groups from a phosphatidylinositol.
|
1 | Q9Z2C5 (/ISO) |
|
Mitochondrion distribution GO:0048311
Any process that establishes the spatial arrangement of mitochondria between and within cells.
|
1 | Q9Z2C5 (/ISO) |
|
Positive regulation of skeletal muscle tissue growth GO:0048633
Any process that activates, maintains or increases the rate of skeletal muscle growth.
|
1 | Q9Z2C5 (/IMP) |
|
Negative regulation of protein kinase B signaling GO:0051898
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
1 | Q9Z2C5 (/IMP) |
|
Mitochondrion morphogenesis GO:0070584
The process in which the anatomical structures of a mitochondrion are generated and organized.
|
1 | Q13496 (/IDA) |
|
Mitochondrion morphogenesis GO:0070584
The process in which the anatomical structures of a mitochondrion are generated and organized.
|
1 | Q9Z2C5 (/IMP) |
|
Mitochondrion morphogenesis GO:0070584
The process in which the anatomical structures of a mitochondrion are generated and organized.
|
1 | Q9Z2C5 (/ISO) |
|
Negative regulation of autophagosome assembly GO:1902902
Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly.
|
1 | Q9Z2C5 (/IMP) |
There are 21 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
|
3 | A6QLT4 (/ISS) Q5R9S3 (/ISS) Q9Z2C5 (/ISS) |
|
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
|
3 | A6QLT4 (/ISS) Q5R9S3 (/ISS) Q9Z2C5 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | A6QLT4 (/ISS) Q5R9S3 (/ISS) Q9Z2C5 (/ISS) |
|
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
|
3 | A6QLT4 (/ISS) Q5R9S3 (/ISS) Q9Z2C5 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q13496 (/IDA) Q9Z2C5 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | A6QLT4 (/ISS) Q5R9S3 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | A0A024RC06 (/IDA) Q13496 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | A0A024RC06 (/IDA) Q13496 (/IDA) |
|
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
|
1 | Q13496 (/IDA) |
|
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
|
1 | Q9Z2C5 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9Z2C5 (/ISO) |
|
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
|
1 | Q13496 (/IDA) |
|
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
|
1 | Q9Z2C5 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9Z2C5 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q13496 (/TAS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q9Z2C5 (/ISO) |
|
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
|
1 | Q13496 (/IDA) |
|
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
|
1 | Q9Z2C5 (/ISO) |
|
I band GO:0031674
A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.
|
1 | Q9Z2C5 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q13496 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q9Z2C5 (/ISO) |
