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CATH Superfamily 3.90.180.10

Medium-chain alcohol dehydrogenases, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Medium-chain alcohol dehydrogenases, catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8363: Crotonyl-CoA reductase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Crotonyl-CoA reductase. [EC: 1.3.1.86]
Butanoyl-CoA + NADP(+) = (E)-but-2-enoyl-CoA + NADPH.
  • Catalyzes the reaction in the reverse direction.
  • This enzyme from Streptomyces collinus is specific for (E)-but-2- enoyl-CoA, and is proposed to provide butanoyl-CoA as a starter unit for straight-chain fatty acid biosynthesis.
 18 A0A075UPV3 A0A089XDT3 A0A0K2B1Z9 A0A0U5GYR9 A0A0U5HFQ2 A0A100J0P4 A0A177HM16 A0A1B2GNL8 A0A1B9F0L7 A0A1C5D613
(8 more...)
Crotonyl-CoA carboxylase/reductase. [EC: 1.3.1.85]
(2S)-ethylmalonyl-CoA + NADP(+) = (E)-but-2-enoyl-CoA + CO(2) + NADPH.
  • The reaction is catalyzed in the reverse direction.
  • This enzyme, isolated from the bacterium Rhodobacter sphaeroides, catalyzes (E)-but-2-enoyl-CoA-dependent oxidation of NADPH in the presence of CO(2).
  • When CO(2) is absent, the enzyme catalyzes the reduction of (E)-but- 2-enoyl-CoA to butanoyl-CoA, but with only 10% of maximal activity (relative to (E)-but-2-enoyl-CoA carboxylation).
 9 A0A0S1UF61 A0A0U1XP65 A0A0X3WXQ2 A0A126XX42 A0A1C4JNT2 A0A1C4MFB2 A0A1C4P363 D6AYT7 K1VTP7