View in Gene3D

CATH Superfamily 3.90.180.10

Medium-chain alcohol dehydrogenases, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Medium-chain alcohol dehydrogenases, catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 8256: Glucose 1-dehydrogenase 1

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glucose 1-dehydrogenase (NAD(P)(+)). [EC: 1.1.1.47]
D-glucose + NAD(P)(+) = D-glucono-1,5-lactone + NAD(P)H.
  • This enzyme has similar activity with either NAD(+) or NADP(+).
  • Cf. EC 1.1.1.118 and EC 1.1.1.119.
 14 A0A0E3KBM2 C3ML78 C3MSD9 C3N1Q7 C3NAE0 C3NL61 C4KL77 D0KQM7 D2PGD1 F0NCS1
(4 more...)
D-galactose 1-dehydrogenase. [EC: 1.1.1.48]
D-galactose + NAD(+) = D-galactono-1,4-lactone + NADH.
  • This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose.
 4 A0A0E3KBM2 D0KQM7 O93715 Q7LYI9
Aldose 1-dehydrogenase (NAD(P)(+)). [EC: 1.1.1.359]
An aldopyranose + NAD(P)(+) = an aldono-1,5-lactone + NAD(P)H.
  • The enzyme from the archaeon Sulfolobus solfataricus shows broad specificity toward aldoses (D-glucose, D-galactose, D-xylose, L-arabinose, 6-deoxy-D-glucose, D-fucose) and can utilize NAD(+) and NADP(+) with similar catalytic efficiency.
  • It is involved in aldose catabolism via the branched variant of the Entner-Doudoroff pathway.
 4 A0A0E3KBM2 D0KQM7 O93715 Q7LYI9
Galactose 1-dehydrogenase (NADP(+)). [EC: 1.1.1.120]
D-galactose + NADP(+) = D-galactono-1,5-lactone + NADPH.
  • Also acts on L-arabinose, 6-deoxy- and 2-deoxy-D-galactose.
 4 A0A0E3KBM2 D0KQM7 O93715 Q7LYI9