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CATH Superfamily 3.90.180.10

Medium-chain alcohol dehydrogenases, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Medium-chain alcohol dehydrogenases, catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 34040: Quinone oxidoreductase 1

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
NADPH:quinone reductase. [EC: 1.6.5.5]
NADPH + 2 quinone = NADP(+) + 2 semiquinone.
  • Specific for NADPH.
  • Catalyzes the one-electron reduction of certain quinones, with the orthoquinones 1,2-naphthoquinone and 9,10-phenanthrenequinone being the best substrates.
  • Dicoumarol (cf. EC 1.6.5.2) and nitrofurantoin are competitive inhibitors with respect to the quinone substrate.
  • The semiquinone free-radical product may be non-enzymically reduced to the hydroquinone or oxidized back to quinone in the presence of O(2).
  • Abundant in the lens of the eye of some mammalian species.
 507 A0A011PZM0 A0A017I957 A0A022PKU1 A0A023Z726 A0A024HA45 A0A024KMH8 A0A025C5B2 A0A026S2J1 A0A027TPN6 A0A028AN49
(497 more...)
L-lactate dehydrogenase. [EC: 1.1.1.27]
(S)-lactate + NAD(+) = pyruvate + NADH.
  • Also oxidizes other (S)-2-hydroxymonocarboxylic acids.
  • NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.
 1 G8PX85
DNA-3-methyladenine glycosylase I. [EC: 3.2.2.20]
Hydrolysis of alkylated DNA, releasing 3-methyladenine.
    		 1 G8PX85