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CATH Superfamily 3.90.180.10

Medium-chain alcohol dehydrogenases, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Medium-chain alcohol dehydrogenases, catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 34038: Probable NADP-dependent isopropanol dehydrogenase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Isopropanol dehydrogenase (NADP(+)). [EC: 1.1.1.80]
Propan-2-ol + NADP(+) = acetone + NADPH.
  • Also acts on other short-chain secondary alcohols and, slowly, on primary alcohols.
 14 A0A097AU74 A0A0B7H1Q9 A0A0G4KAW2 A0A162LBN2 A0A193F8V6 A0A1A6AUY0 A9Q1Y5 C0QV24 D8GLX0 P14941
(4 more...)
Alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.2]
An alcohol + NADP(+) = an aldehyde + NADPH.
  • Some members of this group oxidize only primary alcohols; others act also on secondary alcohols.
  • May be identical with EC 1.1.1.19, EC 1.1.1.33 and EC 1.1.1.55.
  • Re-specific with respect to NADPH.
 13 A0A095ZYS1 A0A0C2NR97 A0A0T6E045 A7GHC5 B0E5T4 B0EUV0 B1ILH2 B2TI97 F0HAS9 F2KUC5
(3 more...)
Alcohol dehydrogenase. [EC: 1.1.1.1]
(1) An alcohol + NAD(+) = an aldehyde or ketone + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
  • Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol.
  • The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
 5 A0A162LBN2 A0A1A6AUY0 D8GLX0 F0F415 U5RQB1