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CATH Superfamily 3.90.180.10

Medium-chain alcohol dehydrogenases, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Medium-chain alcohol dehydrogenases, catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 33782: Geraniol dehydrogenase GeoA

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Alcohol dehydrogenase. [EC: 1.1.1.1]
(1) An alcohol + NAD(+) = an aldehyde or ketone + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
  • Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol.
  • The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
 2 H1ZV38 W8X532
Geraniol dehydrogenase (NAD(+)). [EC: 1.1.1.347]
Geraniol + NAD(+) = geranial + NADH.
  • The enzyme from the bacterium Castellaniella defragrans is most active in vitro with perillyl alcohol.
  • The enzyme from the prune mite Carpoglyphus lactis also acts (more slowly) on farnesol but not on nerol.
  • Formerly EC 1.1.1.n14.
 2 H1ZV38 W8X532
Perillyl-alcohol dehydrogenase. [EC: 1.1.1.144]
Perillyl alcohol + NAD(+) = perillyl aldehyde + NADH.
  • Oxidizes a number of primary alcohols with the alcohol group allylic to an endocyclic double bond and a 6-membered ring, either aromatic or hydroaromatic.
 2 H1ZV38 W8X532
Aryl-alcohol dehydrogenase. [EC: 1.1.1.90]
An aromatic alcohol + NAD(+) = an aromatic aldehyde + NADH.
  • A group of enzymes with broad specificity toward primary alcohols with an aromatic or cyclohex-1-ene ring, but with low or no activity toward short-chain aliphatic alcohols.
 2 P39849 Q7AXU5