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CATH Superfamily 3.90.180.10

Medium-chain alcohol dehydrogenases, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Medium-chain alcohol dehydrogenases, catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 33772: Alcohol dehydrogenase 2, putative, expressed

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Alcohol dehydrogenase. [EC: 1.1.1.1]
(1) An alcohol + NAD(+) = an aldehyde or ketone + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
  • Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol.
  • The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
 251 A0A0B2P735 A0A0B2PMG9 A0A0B2PNL1 A0A0B2Q6K1 A0A0B2QUT8 A0A0B2RGT5 A0A0B2SI48 A0A0B2SJ43 A0A0D3HJH2 A0A0E0HCF7
(241 more...)
S-(hydroxymethyl)glutathione dehydrogenase. [EC: 1.1.1.284]
S-(hydroxymethyl)glutathione + NAD(P)(+) = S-formylglutathione + NAD(P)H.
  • The substrate, S-(hydroxymethyl)glutathione, forms spontaneously from glutathione and formaldehyde; its rate of formation is increased in some bacteria by the presence of EC 4.4.1.22.
  • Forms part of the pathway that detoxifies formaldehyde, since the product is hydrolyzed by EC 3.1.2.12.
  • Also specifically reduces S-nitrosylglutathione.
  • Formerly EC 1.2.1.1.
 6 A0A0B2PNL1 B7ST71 B9SJJ8 B9SJK2 B9T7D8 I1MAE6
UDP-glucose 6-dehydrogenase. [EC: 1.1.1.22]
UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH.
  • Also acts on UDP-2-deoxyglucose.
 1 Q6IVK8