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CATH Superfamily 3.90.180.10

Medium-chain alcohol dehydrogenases, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Medium-chain alcohol dehydrogenases, catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 33771: Probable zinc-containing alcohol dehydrogenase

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Alcohol dehydrogenase. [EC: 1.1.1.1]
(1) An alcohol + NAD(+) = an aldehyde or ketone + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
  • Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol.
  • The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
 34 A0A068YXA4 A0A098FYV1 A0A0A8RME7 A0A0J6Q540 A0A157SJN1 A0A1C2KE37 A0A1D3JY92 A2SHI1 A9IPS4 C3X9D4
(24 more...)
Isopropanol dehydrogenase (NADP(+)). [EC: 1.1.1.80]
Propan-2-ol + NADP(+) = acetone + NADPH.
  • Also acts on other short-chain secondary alcohols and, slowly, on primary alcohols.
 17 A0A0B7D951 A0A0H3QQP5 A0A0Q9YXS1 A0A0U3SER1 A0A109ULH2 A0A142BWH1 A0A143PN29 A0A1D5C1U5 A0A1E3GPL3 A0A1E9BUM9
(7 more...)
Alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.2]
An alcohol + NADP(+) = an aldehyde + NADPH.
  • Some members of this group oxidize only primary alcohols; others act also on secondary alcohols.
  • May be identical with EC 1.1.1.19, EC 1.1.1.33 and EC 1.1.1.55.
  • Re-specific with respect to NADPH.
 11 A0A0J6Q540 A0A0M7NPG7 A0A0T8KX47 A0A0U7M8Y0 A0A137YFK5 A0A157SJN1 F4GEY3 G2IPG9 G7ZBG0 Q7NWD9
(1 more...)
Aldehyde dehydrogenase (NAD(+)). [EC: 1.2.1.3]
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
  • Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.
  • Formerly EC 1.1.1.70.
 3 P14940 Q0KDL6 R7XEP2
(R,R)-butanediol dehydrogenase. [EC: 1.1.1.4]
(R,R)-butane-2,3-diol + NAD(+) = (R)-acetoin + NADH.
  • Also converts diacetyl into acetoin with NADH as reductant.
 3 P14940 Q0KDL6 R7XEP2
5-exo-hydroxycamphor dehydrogenase. [EC: 1.1.1.327]
5-exo-hydroxycamphor + NAD(+) = bornane-2,5-dione + NADH.
  • Isolated from Pseudomonas putida, and involved in degradation of (+)- camphor.
 1 W7WZ53