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CATH Superfamily 3.90.1200.10

Aminoglycoside phosphotransferase (APH), C-terminal lobe

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9598: Hygromycin resistance protein

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Hygromycin B 4-O-kinase. [EC: 2.7.1.163]
ATP + hygromycin B = ADP + 4-O-phosphohygromycin B.
  • Phosphorylates the antibiotic hygromycin B.
  • Whereas the enzyme from Streptomyces hygroscopicus (EC 2.7.1.119) catalyzes the formation of 7''-O-phosphohygromycin B, this enzyme, found in Escherichia coli carrying a plasmid conferring resistance to hygromycin-B, forms 4-O-phosphohygromycin B.
  • Formerly EC 2.7.1.n6.
 13 A0A097J0L4 A0A127GU86 A0A142V6E7 A0A172QY28 A0A1C9T7Y7 A0A1L6MH44 B3GVC2 B6D4X0 G0FGT3 H9TI80
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