The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aspartate Aminotransferase, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 81466: Alanine aminotransferase 2, mitochondrial

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-alanine:2-oxoglutarate aminotransferase activity GO:0004021
Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
5 F4I7I0 (/IDA) P0A959 (/IDA) Q8TD30 (/IDA) Q9LR30 (/IDA) Q9S7E9 (/IDA)
L-alanine:2-oxoglutarate aminotransferase activity GO:0004021
Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
5 P71348 (/ISS) Q28DB5 (/ISS) Q6GM82 (/ISS) Q6NYL5 (/ISS) Q8BGT5 (/ISS)
L-alanine:2-oxoglutarate aminotransferase activity GO:0004021
Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
2 P24298 (/EXP) Q8TD30 (/EXP)
L-alanine:2-oxoglutarate aminotransferase activity GO:0004021
Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
2 P52893 (/IMP) Q9LR30 (/IMP)
L-alanine:2-oxoglutarate aminotransferase activity GO:0004021
Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
2 Q8BGT5 (/ISO) Q8QZR5 (/ISO)
L-alanine:2-oxoglutarate aminotransferase activity GO:0004021
Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
2 P24298 (/NAS) P25409 (/NAS)
Alanine-glyoxylate transaminase activity GO:0008453
Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine.
2 Q9LR30 (/IDA) Q9S7E9 (/IDA)
Glycine:2-oxoglutarate aminotransferase activity GO:0047958
Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate.
2 Q9LR30 (/IDA) Q9S7E9 (/IDA)
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
1 Q9KQM1 (/ISS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 F4I7I0 (/IDA)
Transaminase activity GO:0008483
Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
1 P0A959 (/IMP)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
1 P0A959 (/IDA)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
1 P25409 (/NAS)
Glycine:2-oxoglutarate aminotransferase activity GO:0047958
Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate.
1 Q9LR30 (/IMP)
Glycine:2-oxoglutarate aminotransferase activity GO:0047958
Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate.
1 Q9S7E9 (/ISS)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
2-oxoglutarate metabolic process GO:0006103
The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
4 Q28DB5 (/ISS) Q6GM82 (/ISS) Q6NYL5 (/ISS) Q8BGT5 (/ISS)
L-alanine metabolic process GO:0042851
The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.
4 Q28DB5 (/ISS) Q6GM82 (/ISS) Q6NYL5 (/ISS) Q8BGT5 (/ISS)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
3 F4I7I0 (/IEP) Q9LDV4 (/IEP) Q9LR30 (/IEP)
D-alanine biosynthetic process GO:0030632
The chemical reactions and pathways resulting in the formation of D-alanine, the D-enantiomer of the amino acid alanine, i.e (2R)-2-aminopropanoic acid.
3 P0A960 (/ISS) P0A961 (/ISS) P71348 (/ISS)
Alanine biosynthetic process GO:0006523
The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid.
2 P0A959 (/IMP) P52893 (/IMP)
Cellular amino acid biosynthetic process GO:0008652
The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
2 P24298 (/TAS) Q8TD30 (/TAS)
Chronological cell aging GO:0001300
The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state.
1 P52893 (/IMP)
2-oxoglutarate metabolic process GO:0006103
The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
1 Q8TD30 (/IDA)
2-oxoglutarate metabolic process GO:0006103
The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
1 Q8BGT5 (/ISO)
Alanine catabolic process GO:0006524
The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid.
1 P52893 (/IMP)
Aspartate biosynthetic process GO:0006532
The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
1 Q9KQM1 (/ISS)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
1 P0A959 (/IMP)
Photorespiration GO:0009853
A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria.
1 Q9LR30 (/TAS)
L-alanine biosynthetic process from pyruvate GO:0019272
The chemical reactions and pathways resulting in the formation of alanine from other compounds, including pyruvate.
1 P0A959 (/IMP)
L-alanine catabolic process, by transamination GO:0019481
The chemical reactions and pathways resulting in the breakdown of L-alanine by transamination.
1 F4I7I0 (/IMP)
D-alanine biosynthetic process GO:0030632
The chemical reactions and pathways resulting in the formation of D-alanine, the D-enantiomer of the amino acid alanine, i.e (2R)-2-aminopropanoic acid.
1 P0A959 (/IMP)
L-alanine metabolic process GO:0042851
The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.
1 Q8TD30 (/IDA)
L-alanine metabolic process GO:0042851
The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.
1 Q8BGT5 (/ISO)
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
1 P0A959 (/IMP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 F4I7I0 (/IEP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 F4I7I0 (/IDA) P52893 (/IDA) Q7KV27 (/IDA) Q8BGT5 (/IDA) Q9VYD9 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
3 F4I7I0 (/IDA) Q9LR30 (/IDA) Q9S7E9 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
2 Q9LR30 (/IDA) Q9S7E9 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q7KV27 (/IDA) Q9VYD9 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q8QZR5 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q8TD30 (/TAS)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
1 Q9LR30 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
1 Q9S7E9 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P24298 (/TAS)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
1 Q9S7E9 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9LR30 (/IDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
1 Q9LR30 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P24298 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q8QZR5 (/ISO)