View in Gene3D

CATH Superfamily 3.90.1150.10

Aspartate Aminotransferase, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aspartate Aminotransferase, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 80782: Uncharacterized aminotransferase C6B12.04c

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Kynurenine--oxoglutarate transaminase. [EC: 2.6.1.7]
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
  • Also acts on 3-hydroxykynurenine.
  • The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
 3 G2WGV6 P47039 Q54KM6
Glutamine--phenylpyruvate transaminase. [EC: 2.6.1.64]
L-glutamine + phenylpyruvate = 2-oxoglutaramate + L-phenylalanine.
  • L-methionine, L-histidine and L-tyrosine can act as donors.
  • Has little activity on pyruvate and glyoxylate (cf. EC 2.6.1.15).
 1 Q54KM6
Cysteine-S-conjugate beta-lyase. [EC: 4.4.1.13]
An L-cysteine-S-conjugate + H(2)O = RSH + NH(3) + pyruvate.
  • The enzyme can act on a broad range of L-cysteine-S-conjugates, including aromatic conjugates such as 4-bromobenzene and 2,4- dinitrobenzene.
  • The enzyme cleaves a carbon-sulfur bond, releasing a thiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
  • The latter reaction, which can occur spontaneously, can also be catalyzed by EC 3.5.99.10.
 1 Q54KM6