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CATH Superfamily 3.90.1150.10

Aspartate Aminotransferase, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aspartate Aminotransferase, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 62411: Low specificity L-threonine aldolase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
L-threonine aldolase. [EC: 4.1.2.5]
L-threonine = glycine + acetaldehyde.
  • This enzyme is specific for L-threonine and can not utilize L-allo- threonine.
  • Different from EC 4.1.2.49 and EC 4.1.2.48.
 9 A0A0E4C686 A0A0H3AG20 A0A0H3Q5H4 A0A0H3ZRW4 A0A0H6LNY0 A0A0K9UPQ9 A0A0X1L0M1 C2I008 Q9KLH9
L-allo-threonine aldolase. [EC: 4.1.2.49]
L-allo-threonine = glycine + acetaldehyde.
  • This enzyme, characterized from the bacterium Aeromonas jandaei, is specific for L-allo-threonine and can not act on either L-threonine or L-serine.
  • Different from EC 4.1.2.5 and EC 4.1.2.48.
  • A previously listed enzyme with this name, EC 4.1.2.6, was deleted in 1971 after it was found to be identical to EC 2.1.2.1.
 4 A0A0H6GQT2 A0A0H6N1C4 A0A0H6WAC4 A0A0H6YSW2
Low-specificity L-threonine aldolase. [EC: 4.1.2.48]
(1) L-threonine = glycine + acetaldehyde. (2) L-allo-threonine = glycine + acetaldehyde.
  • The low-specificity L-threonine aldolase can act on both L-threonine and L-allo-threonine.
  • The enzyme from Escherichia coli can also act on L-threo-phenylserine and L-erythro-phenylserine.
  • The enzyme can also catalyze the aldol condensation of glycolaldehyde and glycine to form 4-hydroxy-L-threonine, an intermediate of pyridoxal phosphate biosynthesis.
  • Different from EC 4.1.2.5 and EC 4.1.2.49.
 1 A0A0H6R3F0
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