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CATH Superfamily 3.90.110.10

Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3050: Malate dehydrogenase MDH

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Malate dehydrogenase. [EC: 1.1.1.37]
(S)-malate + NAD(+) = oxaloacetate + NADH.
  • Also oxidizes some other 2-hydroxydicarboxylic acids.
 807 A0A023CMA8 A0A023X3H2 A0A024KEZ3 A0A024P6Z5 A0A031IHJ5 A0A058ZKA3 A0A059IK58 A0A060LYL1 A0A061N9X4 A0A061NFX1
(797 more...)
L-lactate dehydrogenase. [EC: 1.1.1.27]
(S)-lactate + NAD(+) = pyruvate + NADH.
  • Also oxidizes other (S)-2-hydroxymonocarboxylic acids.
  • NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.
 2 A0A074T5D6 E7CG09