View in Gene3D

CATH Superfamily 3.80.10.10

Ribonuclease Inhibitor

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Ribonuclease Inhibitor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 106500: Disease resistance like protein

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
 5 A0A0B2SU41 C0LGJ8 C0LGQ9 I1KBA7 Q9ZVR7
2-alkenal reductase (NAD(P)(+)). [EC: 1.3.1.74]
A n-alkanal + NAD(P)(+) = an alk-2-enal + NAD(P)H.
  • Highly specific for 4-hydroxynon-2-enal and non-2-enal.
  • Alk-2-enals of shorter chain have lower affinities.
  • Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one.
  • Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid.
  • Involved in the detoxification of alpha,beta-unsaturated aldehydes and ketones (cf. EC 1.3.1.102).
 2 B9RJJ2 B9RY42
Guanylate cyclase. [EC: 4.6.1.2]
GTP = 3',5'-cyclic GMP + diphosphate.
  • Also acts on ITP and dGTP.
 2 C0LGJ8 Q9ZVR7
Receptor protein serine/threonine kinase. [EC: 2.7.11.30]
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
  • The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death.
  • Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase.
  • Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates.
  • Formerly EC 2.7.1.37.
 1 B9RJJ2
Mitogen-activated protein kinase kinase. [EC: 2.7.12.2]
ATP + a protein = ADP + a phosphoprotein.
  • A dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation.
  • It is required for activation of EC 2.7.11.24.
  • Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues.
  • Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation.
  • Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
 1 B9RY42
Protein-serine/threonine phosphatase. [EC: 3.1.3.16]
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
  • A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48).
  • The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).
 1 B9SB23