The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
PPM-type phosphatase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11557: Serine/threonine phosphatase, family 2C

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
14 B3MTI8 (/ISS) B3P5D3 (/ISS) B4G653 (/ISS) B4HZE7 (/ISS) B4JYN1 (/ISS) B4K616 (/ISS) B4M5T5 (/ISS) B4NBL6 (/ISS) B4PPK3 (/ISS) B4R089 (/ISS)
(4 more)
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
4 Q5AME8 (/ISM) Q9VAH4 (/ISM) Q9W0E2 (/ISM) Q9W3R1 (/ISM)
Phosphoprotein phosphatase activity GO:0004721
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
3 Q9VAH4 (/ISS) Q9W0E2 (/ISS) Q9W3R1 (/ISS)
Phosphoprotein phosphatase activity GO:0004721
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
2 P38797 (/IDA) P9WHW5 (/IDA)
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
2 A0A1D8PL06 (/IDA) P38797 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P38797 (/IPI) Q8DGS1 (/IPI)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 P9WHW5 (/IDA)
Phosphoserine phosphatase activity GO:0004647
Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate.
1 P9WHW5 (/IDA)
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
1 Q5AME8 (/ISA)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
1 P9WHW5 (/IDA)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
12 B3MTI8 (/ISS) B3P5D3 (/ISS) B4G653 (/ISS) B4HZE7 (/ISS) B4JYN1 (/ISS) B4K616 (/ISS) B4M5T5 (/ISS) B4NBL6 (/ISS) B4PPK3 (/ISS) B4R089 (/ISS)
(2 more)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
4 Q5AME8 (/IC) Q9VAH4 (/IC) Q9W0E2 (/IC) Q9W3R1 (/IC)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
3 Q9VAH4 (/ISS) Q9W0E2 (/ISS) Q9W3R1 (/ISS)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
2 P38797 (/IDA) P9WHW5 (/IDA)
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
1 P9WHW5 (/IDA)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
1 Q5AME8 (/IMP)
Thylakoid membrane organization GO:0010027
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the thylakoid membrane.
1 O64730 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
1 Q5AME8 (/IMP)
Sorocarp development GO:0030587
The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.
1 Q94489 (/IMP)
Culmination involved in sorocarp development GO:0031154
The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development.
1 Q94489 (/IMP)
Protein secretion by the type VI secretion system GO:0033103
The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.
1 Q9I355 (/IGC)
Peptidyl-threonine dephosphorylation GO:0035970
The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.
1 O64730 (/IDA)
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
1 Q5AME8 (/IMP)
Filamentous growth of a population of unicellular organisms in response to neutral pH GO:0036178
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a neutral pH (pH close to 7) stimulus.
1 Q5AME8 (/IMP)
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
1 Q5AME8 (/IMP)
Cellular response to neutral pH GO:0036244
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
1 Q5AME8 (/IMP)
Positive regulation of catalytic activity GO:0043085
Any process that activates or increases the activity of an enzyme.
1 P9WHW5 (/IDA)
Negative regulation of catalytic activity GO:0043086
Any process that stops or reduces the activity of an enzyme.
1 P9WHW5 (/IDA)
Negative regulation of DNA binding GO:0043392
Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
1 P9WHW5 (/IDA)
Cellular response to light stimulus GO:0071482
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
1 O64730 (/IMP)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 A0A1D8PL06 (/IDA) P38797 (/IDA) Q6NVE9 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q9W0E2 (/ISS) Q9W3R1 (/ISS)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
1 P9WHW5 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 P38797 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q94489 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q585I2 (/RCA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P9WHW5 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 O64730 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
1 O64730 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P9WHW5 (/IDA)
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